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Apoptotic and Chemotherapeutic Properties of Iron (III)-Salophene in an Ovarian Cancer Animal Model

Description: 
The cytotoxicity of organometallic compounds iron(III)-, cobalt(III)-, manganese(II)-, and copper(II)-salophene (-SP) on platinum-resistant ovarian cancer cell lines was compared. Fe-SP displayed selective cytotoxicity (IC(50) at ~1 muM) against SKOV-3 and OVCAR-3 cell lines while Co-SP caused cytotoxic effects only at higher concentrations (IC(50) at 60 muM) and Cu-SP effects were negligible. High cytotoxicity of Mn-SP (30-60 muM) appeared to be nonspecific because the Mn-chloride salt reduced cell viability similarly. The effect of Fe-SP at 1 muM proved to be ovarian cancer cell selective when compared to a panel of cell lines derived from different tumors. The first irreversible step in the induction of cell death by Fe-SP occurred after 3 hrs as indicated by the mitochondrial transmembrane potential (DeltaPsim) and was mainly linked to apoptotic, not necrotic events. To evaluate the toxicity of Fe-SP in vivo we conducted an acute toxicity study in rats. The LD(50) of Fe-SP is >2000 mg/kg orally and >5.5 mg/kg body weight by intraperitoneal injection. An ovarian cancer animal model showed that the chemotherapeutic relevant dose of Fe-SP in rats is 0.5-1 mg/kg body weight. The present report suggests that Fe-SP is a potential therapeutic drug to treat ovarian cancer.
Record Format: 
application/pdf
2009-09-01T07:00:00Z
Subject: 
Ovaries -- Cancer
Chemotherapy
Cancer -- Treatment -- Research
Medicinal Chemistry and Pharmaceutics
Medicinal-Pharmaceutical Chemistry
Type: 
text
Raw Url: 
http://pdxscholar.library.pdx.edu/do/oai/?metadataPrefix=&verb=GetRecord&identifier=oai:pdxscholar.library.pdx.edu:chem_fac-1058
Source: 
Chemistry Faculty Publications and Presentations
Repository Record Id: 
oai:pdxscholar.library.pdx.edu:chem_fac-1058
SetSpec: 
publication:chem
publication:clas
publication:communities
publication:chem_fac
Record Title: 
Apoptotic and Chemotherapeutic Properties of Iron (III)-Salophene in an Ovarian Cancer Animal Model
https://pdxscholar.library.pdx.edu/chem_fac/59
info:doi/10.2147/DDDT.S4582
https://pdxscholar.library.pdx.edu/context/chem_fac/article/1058/viewcontent/strongin_apoptotic.pdf
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