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Competition for hydrogen-bond formation in the helix-coil transition and protein folding

Description: 
The problem of the helix-coil transition of biopolymers in explicit solvents, such as water, with the ability for hydrogen bonding with a solvent is addressed analytically using a suitably modified version of the Generalized Model of Polypeptide Chains. Besides the regular helix-coil transition, an additional coil-helix or reentrant transition is also found at lower temperatures. The reentrant transition arises due to competition between polymer-polymer and polymer-water hydrogen bonds. The balance between the two types of hydrogen bonding can be shifted to either direction through changes not only in temperature, but also by pressure, mechanical force, osmotic stress, or other external influences. Both polypeptides and polynucleotides are considered within a unified formalism. Our approach provides an explanation of the experimental difficulty of observing the reentrant transition with pressure and underscores the advantage of pulling experiments for studies of DNA. Results are discussed and compared with those reported in a number of recent publications with which a significant level of agreement is obtained.
Record Format: 
application/pdf
Record Date: 
2011-05-01T07:00:00Z
Publisher: 
PDXScholar
Subject: 
Biopolymers -- Physiological transport
Biopolymers
Solvents -- Hydrogen bonding
Biochemistry
Type: 
text
Raw Url: 
https://pdxscholar.library.pdx.edu/do/oai/?metadataPrefix=&verb=GetRecord&identifier=oai:pdxscholar.library.pdx.edu:chem_fac-1033
Source: 
Chemistry Faculty Publications and Presentations
Repository Record Id: 
oai:pdxscholar.library.pdx.edu:chem_fac-1033
SetSpec: 
publication:clas
publication:communities
publication:chem_fac
publication:chem
Record Title: 
Competition for hydrogen-bond formation in the helix-coil transition and protein folding
Identifier: 
https://pdxscholar.library.pdx.edu/chem_fac/34
https://pdxscholar.library.pdx.edu/cgi/viewcontent.cgi?article=1033&context=chem_fac
Author: 
Badasyan, A. V.
Tonoyan, S. A.
Mamasakhlisov, Y. S.
Giacometti, A.
Benight, Albert S.
Morozov, V. F.
Database: 
Resource OE Format: 
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