Description:
When RNA is replicated in cell-free systems, a ubiquitous problem is the hijacking of the system by short parasitic RNA sequences. In this issue of Chemistry & Biology, Bansho et al. show that compartmentalization into water-in-oil droplets can ameliorate this problem, but only if the droplets are small. This result helps to both recapitulate abiogenesis and optimize synthetic biology.
Refers to: Bansho, Yohsuke, et al. "Importance of Parasite RNA Species Repression for Prolonged Translation-Coupled RNA Self-Replication." Chemistry & Biology 19.4 (2012): 478-487.
Subject:
RNA -- Biology
RNA -- Evolution
Evolutionary genetics
Biochemistry, Biophysics, and Structural Biology
Raw Url:
http://pdxscholar.library.pdx.edu/do/oai/?metadataPrefix=&verb=GetRecord&identifier=oai:pdxscholar.library.pdx.edu:chem_fac-1045
Source:
Chemistry Faculty Publications and Presentations
Repository Record Id:
oai:pdxscholar.library.pdx.edu:chem_fac-1045
Record Title:
Evolution Finds Shelter in Small Spaces
https://pdxscholar.library.pdx.edu/chem_fac/45
info:doi/10.1016/j.chembiol.2012.04.002
https://pdxscholar.library.pdx.edu/context/chem_fac/article/1045/viewcontent/lehman_evolution_finds_shelter_in_small_spaces_Open_Archive.pdf