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A Fast Response Highly Selective Probe for the Detection of Glutathione in Human Blood Plasma

Description: 
A fluorescent probe for glutathione (GSH) detection was developed. Our study indicates a possible mechanism which couples a conjugate addition and micelle-catalyzed large membered ring formation/elimination sequence. This method enables excellent selectivity towards GSH over other biological thiols such as cysteine (Cys) and homocysteine (Hcy). The proposed method is precise with a relative standard deviation (R.S.D) lower than 6% (n = 3) and has been successfully applied to determine GSH in human plasma with recoveries between 99.2% and 102.3%.
Record Format: 
application/pdf
Record Date: 
2012-05-01T07:00:00Z
Publisher: 
PDXScholar
Subject: 
Fluorescence spectroscopy
Sulfur amino acids
Molecular probes
Biochemistry
Chemistry
Type: 
text
Raw Url: 
https://pdxscholar.library.pdx.edu/do/oai/?metadataPrefix=&verb=GetRecord&identifier=oai:pdxscholar.library.pdx.edu:chem_fac-1050
Source: 
Chemistry Faculty Publications and Presentations
Repository Record Id: 
oai:pdxscholar.library.pdx.edu:chem_fac-1050
SetSpec: 
publication:clas
publication:communities
publication:chem_fac
publication:chem
Record Title: 
A Fast Response Highly Selective Probe for the Detection of Glutathione in Human Blood Plasma
Identifier: 
https://pdxscholar.library.pdx.edu/chem_fac/51
https://pdxscholar.library.pdx.edu/cgi/viewcontent.cgi?article=1050&context=chem_fac
Author: 
Guo, Yixing
Yang, Xiaofeng
Hakuna, Lovemore
Barve, Aabha
Escobedo, Jorge O.
Lowry, Mark
Strongin, Robert M.
Database: 
Resource OE Format: 
randomness