You are here

Thiol Reactive Probes and Chemosensors

Description: 
Thiols are important molecules in the environment and in biological processes. Cysteine (Cys), homocysteine (Hcy), glutathione (GSH) and hydrogen sulfide (H2S) play critical roles in a variety of physiological and pathological processes. The selective detection of thiols using reaction-based probes and sensors is very important in basic research and in disease diagnosis. This review focuses on the design of fluorescent and colorimetric probes and sensors for thiol detection. Thiol detection methods include probes and labeling agents based on nucleophilic addition and substitution, Michael addition, disulfide bond or Se-N bond cleavage, metal-sulfur interactions and more. Probes for H2S are based on nucleophilic cyclization, reduction and metal sulfide formation. Thiol probe and chemosensor design strategies and mechanism of action are discussed in this review.
Record Format: 
application/pdf
Record Date: 
2012-11-01T07:00:00Z
Publisher: 
PDXScholar
Subject: 
Thiols -- Detection
Thiols -- Research
Fluorescence spectroscopy
Chemical detectors
Biosensors -- Design
Biochemical and Biomolecular Engineering
Type: 
text
Raw Url: 
https://pdxscholar.library.pdx.edu/do/oai/?metadataPrefix=&verb=GetRecord&identifier=oai:pdxscholar.library.pdx.edu:chem_fac-1027
Source: 
Chemistry Faculty Publications and Presentations
Repository Record Id: 
oai:pdxscholar.library.pdx.edu:chem_fac-1027
SetSpec: 
publication:clas
publication:communities
publication:chem_fac
publication:chem
Record Title: 
Thiol Reactive Probes and Chemosensors
Identifier: 
https://pdxscholar.library.pdx.edu/chem_fac/28
https://pdxscholar.library.pdx.edu/cgi/viewcontent.cgi?article=1027&context=chem_fac
Author: 
Strongin, Robert M.
Hakuna, Lovemore
Peng, Hanjing
Chen, Weixuan
Cheng, Yunfeng
Wang, Binghe
Database: 
Resource OE Format: 
randomness