Conservation

Conservation

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  1. Antisense transcription is pervasive but rarely conserved in enteric bacteria

    Noncoding RNAs, including antisense RNAs (asRNAs) that originate from the complementary strand of protein-coding genes, are involved in the regulation of gene expression in all domains of life. Recent...

  2. The Intervening Sequence of <i>Coxiella burnetii</i>: Characterization and Evolution

    The intervening sequence (IVS) of Coxiella burnetii, the agent of Q fever, is a 428-nt selfish genetic element located in helix 45 of the precursor 23S rRNA. The IVS element, in turn, contains an ORF that...

  3. Identification of Novel Small RNAs and Characterization of the 6S RNA of Coxiella burnetii

    Coxiella burnetii, an obligate intracellular bacterial pathogen that causes Q fever, undergoes a biphasic developmental cycle that alternates between a metabolically-active large cell variant (LCV) and a...

  4. Genome-Wide Detection of Novel Regulatory RNAs in E. Coli

    The intergenic regions in bacterial genomes can contain regulatory leader sequences and small RNAs (sRNAs), which both serve to modulate gene expression. Computational analyses have predicted the presence of...

  5. Genome Rearrangements Can Make and Break Small RNA Genes

    Small RNAs (sRNAs) are short, transcribed regulatory elements that are typically encoded in the intergenic regions (IGRs) of bacterial genomes. Several sRNAs, first recognized in Escherichia coli, are conserved...