Description:
A mild and metal-free approach to C−N coupling is described that employs diaryliodonium salt electrophiles and secondary aliphatic amine nucleophiles. This reaction results in direct ipso-substitution of the iodonium moiety and unsymmetrical aryl(TMP)iodonium salts are primarily employed. Moreover, arene substituents and substitution patterns that currently pose a challenge to classical metal-free methods are accommodated and the alicyclic amine nucleophiles used here are unprecedented in other contemporary metal-free C−N coupling reactions.
Raw Url:
http://pdxscholar.library.pdx.edu/do/oai/?metadataPrefix=&verb=GetRecord&identifier=oai:pdxscholar.library.pdx.edu:chem_fac-1171
Source:
Chemistry Faculty Publications and Presentations
Repository Record Id:
oai:pdxscholar.library.pdx.edu:chem_fac-1171
Record Title:
Metal-free Synthesis of Aryl Amines: Beyond Nucleophilic Aromatic Substitution
https://pdxscholar.library.pdx.edu/chem_fac/170
info:doi/10.1002/anie.201610086