Description:
This tutorial review examines the fundamental aspects of a new class of contrast media for MRI based upon the chemical shift saturation transfer (CEST) mechanism. Several paramagnetic versions called PARACEST agents have shown utility as responsive agents for reporting physiological or metabolic information by MRI. It is shown that basic NMR exchange theory can be used to predict how parameters such as chemical shift, bound water lifetimes, and relaxation rates can be optimized to maximize the sensitivity of PARACEST agents.
Raw Url:
http://pdxscholar.library.pdx.edu/do/oai/?metadataPrefix=&verb=GetRecord&identifier=oai:pdxscholar.library.pdx.edu:chem_fac-1417
Source:
Chemistry Faculty Publications and Presentations
Repository Record Id:
oai:pdxscholar.library.pdx.edu:chem_fac-1417
Record Title:
Paramagnetic Lanthanide Complexes as PARACEST Agents for Medical Imaging
https://pdxscholar.library.pdx.edu/chem_fac/415
info:doi/10.1039/B509907M